Oracle Linux 5.6 on VBox 4.3.12, on Windows 7 Pro, 64bit with 16gb of memory.
I've been picking at this problem for quite some time. Posted some time back on the vbox.org forum, then later on the OTN Vbox forum when I discovered it. No help there so thought I'd try attacking it from a Linux point of view.
First off --
oracle:+ASM$ uname -a
Linux vbdwprod.vbdomain 2.6.18-238.1.1.0.1.el5 #1 SMP Thu Jan 20 23:52:48 EST 2011 x86_64 x86_64 x86_64 GNU/Linux
Here's the problem. After a VM has been up for a while it throws the following:

And the real frustration comes in that I can anticipate when it will throw this error because everything -- and I mean everything - else running on the host comes grinding to a halt. Most other applications will start showing "Not responding". Even if they don't show that in their title bar, they do stop responding. Even getting Windows Task Manager up can be painfully slow, and when it does come up, it shows no stress on the CPU - still up around 95% idle.
I'm thinking some sort of clock timing issue between the guest and host, but that is really outside of my expertise. I do add 'divisor=10' to my grub.conf as part of the initial build of all my vm's.
So, does anyone have any ideas what all this means and how I might address it?