Enterprise Manager

Hello,
I have a proble with my OEM that could not connect anymore to the Database. First it was connecting.
I have check the instance wihich is running same for the listener.
What could be the problem.
Here is the content of the emoms.trc

2009-04-08 16:38:13,543 [HttpRequestHandler-24422114] ERROR conn.ConnectionService verifyRepositoryEx.433 - Invalid Connection Pool. ERROR = Io exception: The Network Adapter could not establish the connection
2009-04-08 16:38:13,548 [HttpRequestHandler-24422114] WARN jdbc.ConnectionCache _getConnection.303 - Got a fatal exeption when getting a connection; Error code = 17002; Cleaning up cache and retrying
2009-04-08 16:38:13,549 [HttpRequestHandler-24422114] WARN jdbc.ConnectionCache _getConnection.306 - Io exception: The Network Adapter could not establish the connection
java.sql.SQLException: Io exception: The Network Adapter could not establish the connection
at oracle.jdbc.driver.DatabaseError.throwSqlException(DatabaseError.java:111)
at oracle.jdbc.driver.DatabaseError.throwSqlException(DatabaseError.java:145)
at oracle.jdbc.driver.DatabaseError.throwSqlException(DatabaseError.java:254)
at oracle.jdbc.driver.T4CConnection.logon(T4CConnection.java:386)
at oracle.jdbc.driver.PhysicalConnection.<init>(PhysicalConnection.java:493)
at oracle.jdbc.driver.T4CConnection.<init>(T4CConnection.java:164)
at oracle.jdbc.driver.T4CDriverExtension.getConnection(T4CDriverExtension.java:34)
at oracle.jdbc.driver.OracleDriver.connect(OracleDriver.java:767)
at oracle.jdbc.pool.OracleDataSource.getPhysicalConnection(OracleDataSource.java:324)
at oracle.jdbc.pool.OracleConnectionPoolDataSource.getPooledConnection(OracleConnectionPoolDataSource.java:114)
at oracle.jdbc.pool.OracleConnectionCacheImpl.getNewPoolOrXAConnection(OracleConnectionCacheImpl.java:694)
at oracle.jdbc.pool.OracleConnectionCacheImpl.getPooledConnection(OracleConnectionCacheImpl.java:540)
at oracle.jdbc.pool.OracleConnectionCacheImpl.getConnection(OracleConnectionCacheImpl.java:346)
at oracle.jdbc.pool.OracleConnectionCacheImpl.getConnection(OracleConnectionCacheImpl.java:324)
at oracle.sysman.util.jdbc.ConnectionCache._getConnection(ConnectionCache.java:296)
at oracle.sysman.util.jdbc.ConnectionCache.getUnwrappedConnection(ConnectionCache.java:423)
at oracle.sysman.emSDK.svc.conn.FGAConnectionCache.getFGAConnection(FGAConnectionCache.java:156)
at oracle.sysman.emSDK.svc.conn.ConnectionService.getPrivateConnection(ConnectionService.java:605)
at oracle.sysman.emdrep.receiver.OMSHandshake.getParameterFromDB(OMSHandshake.java:387)
at oracle.sysman.emdrep.receiver.OMSHandshake.getMaxAgentCompatVer(OMSHandshake.java:369)
at oracle.sysman.emdrep.receiver.OMSHandshake.handshake(OMSHandshake.java:794)
at oracle.sysman.emdrep.receiver.OMSHandshake.handshake(OMSHandshake.java:648)
at oracle.sysman.emdrep.receiver.FxferRecv.doGet(FxferRecv.java:658)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:740)
at javax.servlet.http.HttpServlet.service(HttpServlet.java:853)
at com.evermind.server.http.ResourceFilterChain.doFilter(ResourceFilterChain.java:65)
at oracle.sysman.eml.app.ContextInitFilter.doFilter(ContextInitFilter.java:239)
at com.evermind.server.http.ServletRequestDispatcher.invoke(ServletRequestDispatcher.java:604)
at com.evermind.server.http.ServletRequestDispatcher.forwardInternal(ServletRequestDispatcher.java:317)


Thanks