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According comment from APEX dev team back in 2022, it's safe to remove those
For (2), you can safely drop WWV_DBMS_SQL_APEX_nnnnnn, where nnnnnn is an older APEX version.
https://forums.oracle.com/ords/apexds/post/sys-wwv-dbms-sql-apex-invalid-for-older-versions-5788
Thank you!