I have encountered this issue in APEX 18.2 and is is also occurring in APEX 19.2. I have set up a demo of the issue here on apex.oracle.com (Username/password = demo/demo)
A select list has a dynamic action on it to enable or disable other items on the page - a checkbox and a text item. When using the mouse in Microsoft Edge to change the select list, the change of enabled/disabled state does not occur immediately for the checkbox, but only after further activity on the page. On other browsers everything works as expected.